Pipeline
Feroscan's pipeline
FERROCIFENS
Owing to the poor outcomes seen in several types of cancers (e.g. epithelial ovarian cancer, EOC) the search for new active principles outside the established avenues is a burning current concern. In our search for innovative organometallics species able to overcome drug resistance to proapoptotic stimuli we have discovered that the remarkable ferrocifen family bearing a redox motif [ferrocenyl-ene-phenol] selectively activated on cancer cells, and therefore revealing their redox environment. Biologically these species can operate via mechanisms related to both apoptosis and senescence depending on several parmeters. This multitargeting property can inhibit resistance. Among the usable organometallic complexes, iron derivatives occupy a privileged position associated with the particular nature of ferrocene, which is a non-toxic, compact and stable aromatic metallocene with redox properties and a bioisostere of benzene.
Liste des services
Feroscan owns exclusive rights on natural compounds (ALK1, ALK2) which show high performances in-vitro
